Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

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Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

The programmed death (PD)-1-PD-1 ligand (PD-L) pathway, which is part of the B7-CD28 family, consists of the PD-1 receptor and its two ligands PD-L1 and PD-L2. Engagement of PD-1 by its ligands inhibits immune responses, and recent work has shown that PD-1 is highly expressed on exhausted T cells during chronic lymphocytic choriomeningitis virus (LCMV) infection in mice. Blockade of this pathwa...

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Defining the T helper functions impaired by programmed death-1 (PD-1) is crucial for understanding its role in defective HIV control and determining the therapeutic potential of targeting this inhibitory pathway. We describe here the relationships among disease stage, levels of PD-1 expression, and reversibility of CD4 T-cell impairment. PD-L1 blockade in vitro enhanced HIV-specific production ...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 2006

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.20061800